Nya metoder för funktionell magnetresonans - isotrop insamling och kvantitativ metodik | Application
Nya metoder för funktionell magnetresonans - isotrop insamling och kvantitativ metodik
Registration number: LIO-10866
Ansökan om enbart Klinik ALF-medel eller i kombination med LFoU-medel 2008
Application started by: Peter Lundberg, 2007-05-31
Professional title at the time of application: Docent, MR-fysiker
Work place at the time of application: Universitetssjukhuset i Linköping, Radiofysik
Last updated / corrected by: Agneta Linghag, 2009-02-17
Application received by: Region Östergötland
Granted and completedGranted and completed
Applicant: Peter Lundberg
Adj Professor, MR-fysiker, Centrum för Kirurgi, Ortopedi och Cancervård, Medicinska fakulteten

Projektinformation

Sammanfattning

In this project we intend to develop the methods for functional magnetic resonance, leading to better representation of tissue function, and also to improved absolute quantitation. Functional magnetic resonance imaging (fMRI) methods is one of the most useful innovations for functional brain research, and it is probably also one of the major advances in science in the last decades. The aim of the proposed project ) is to continue developing the data acquisition methods for fMRI. A specific goal is to further improve magnetic resonance pulse sequence programs for 3D data acquisition for true volume brain activity imaging, in order to better localize different functional centra in the human brain, in relation to pathologies such as tumours, epilepsy, Parkinson, MS, stroke, etc. But the importance of the proposed research is very much also on improving the possibilities for obtaining a better understanding of how the human brain works. The importance of this latter is mainly in the context of normal development of the human brain, as in early development as well as in aging. The focus of the present proposal is not only on improving the acquisition aspects, but also on other methodological aspects such as quality assurance, and new presentation methods, such as visual stereo 3D. The conventional use of magnetic resonance allows only the contrast information to be acquired and visualized as arbitrarily scaled images. One of the principal aims of this project is therefore also to significantly enhance the value of magnetic resonance measurements by scaling the data from magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) correctly to an absolute scale that corresponds to physical reality. This is very valuable because the absolute concentrations of metabolites, as well as water, can then be determined accurately. Such data are extremely important when diagnosing a wide range of diseases directly or indirectly of metabolic origin such as neurological diseases in the brain, heart disease, liver disease, and myopathies. In order to achive such scaling properly, various physical corrective measures has to be developed. We also intend to develop better and faster acquisition techniques, and to develop the applications for dynamic measurements. Applications also for other isotopes than protons are proposed; the proposed methods are very general and can be applied to any MR-detectable isotope of the periodic system of the elements. In addition, the proposed methods will also be very useful for classification and visualization of MRI data, especially applicable on fMRI examinations. This project involves the collaboration between specialists from several fields of research, such as physics, engineering, and medicine.

Referenser

2007Kechagias, S., Ernersson, Å., Dahlqvist, O., Lundberg, P., Lindström, T., Nyström, F. (2007) “Fast food based hyper-alimentation can induce rapid and profound elevations of serum aminotransferase levels in healthy subjects.”, Submission pending to The British Medical Journal.
2007Warntjes, M., Dahlqvist, O., Lundberg, P. (2007) Novel Method for Rapid, Simultaneous T1, T*2, and Proton Density Quantification, Magn Reson Med, 57: 528-537.
2007Engström, M., Landtblom, A.-M., Antepohl, W., Ragnehed, M., Lundberg, P. (2007) Paradigm design of language tests in clinical fMRI to study rehabilitation after stroke. (Submission pending)
2007Ragnehed, M., Håkansson, I., Nilsson, M., Lundberg, P, Söderfeldt, B., Engström, M. (2007) ”Effect of diazepam on clinically designed fMRI”, J Neuropsych Clin Neurosci, 19: 1-9.
2007Noren, B., Dahlqvist, O., Lundberg, P, Almer, S., Kechagias, S., Ekstedt, M., Franzen, L., Wirell, S., Smedby, Ö. (2007) ” 31P MR spectroscopy separates advanced fibrosis from mild fibrosis in diffuse liver disease”, (Final revision to Eur J Radiol).
2007Ragnehed, M., Engström, M., Lundberg, P, Söderfeldt, B., Knutsson, H (2007) ”Performance of canonical correlation analysis in language tests by functional MRI”, (Submission pending).
2007Gustavsson, M., Dahlqvist, O., Jaworski, J., Lundberg, P., Landtblom, A-M, (2007) Low Choline in normal appearing white matter of patients with multiple sclerosis and normal MRI brain scans, Am J Neuroradiol, August issue.
2006Antonsson J, Eriksson O, Lundberg P, Wårdell, K. (2006) “Optical measurements during experimental stereotactic RF-lesioning”, Stereotact Funct Neurosurg, 84: 118-124.
2005Noren, B, Lundberg, P, Ressner, M, Wirell, S, Almer, S, Smedby, Ö (2005) ”Absolute quantification of human liver metabolite concentrations by localized in vivo 31P NMR spectroscopy – with respect to diffuse liver disease.”, Eur J Radiol, 15: 148 - 157. 0
2005Engström, M, Ragnehed, M, Lundberg, P. (2005) “Projection screen or video goggles as stimulus modality in functional magnetic resonance imaging.”, Magn Reson Imag 23: 695-699. 0

Ange forskningsområdet

Radiologi och avbildningsteknik

Decision

Decision date: 2007-11-06

Brief description of each costApplied sumDecision SEKLFoUDecision comment
Allmän forskningsersättning
lön, MR-undersökningar, övriga kostnader såsom etiskt tillstånd mm601 000100 0000ALF 100 tkr
sum601 000100 0000 

Grant providers for application

Forsknings-ALF, ansökningar
Fund group: Radiofysikavdelningen

Contributes with 100000 SEK


Nya metoder för funktionell magnetresonans - isotrop insamling och kvantitativ metodik | Application, from Region Östergötland
http://researchweb.org/is/en/lio/ansokan/10866